Circulating and sc fat SIRT1 changes in T2DM patients.

A, Least squares mean change from baseline of circulating SIRT1 in placebo (gray)- and sildenafil (black)-treated patients. Error bars represent upper and lower 95% CI. *, P < .05 between treatment difference. B, Histograms show the relative quantification of SIRT1/GAPDH gene expression in sc AT before and after treatment (baseline, gray; sildenafil, black). Results are expressed as mean ± SD. *, P < .05. C, Least squares mean change from baseline of circulating adiponectin in placebo (gray)- and sildenafil (black)-treated patients. Error bars represent upper and lower 95% CI. *, P < .05 between treatment difference.