Changes in BMD, P1NP, and serum CTX.

Lumbar spine and total hip BMD increased, whereas the femoral neck did not change and the distal one third radius BMD decreased. Markers remained elevated throughout the 6 years of treatment, although not as high as the initial 1-year peak. P1NP absolute values were: baseline, 44.0 ± 22 μg/L; year 1, 152.3 ± 22 μg/L; and year 6, 86.8 ± 22 μg/L. s-CTX absolute values were: baseline, 303 ± 108; year 1, 587 ± 108; and year 6, 408 ± 128. Data are expressed as mean ± SE. *, P < .05 compared with baseline; †, P < .01 compared with baseline.