Docking of NES within the PR and AR ligand-binding cavity. (A, B) Accommodation mode of NES within the PR LBD (PDB ID: 1A28). The α-helices of the PR LBD are depicted as gray ribbons. (C, D) NES accommodation within the AR LBD (PDB ID: 2AMA). The α-helices of the AR LBD are depicted as blue ribbons. Some residues in the binding pockets are shown with their carbon, oxygen, nitrogen, and sulfur atoms colored in gray, red, blue, and green, respectively. The carbon and oxygen atoms of the ligand NES are colored in gold and red, respectively. The figure panels were generated using the Dino package (DINO: Visualizing Structural Biology 2002) (http://www.dino3d.org). The view in B and D was obtained by applying 90° rotations (around the x and y axis) on the view of A and C.