Visual predictive check of the final quinine model. Open circles represent the observed data, continuous lines represent the 5th, 50th and 95th percentiles of the observed data and shaded areas represent the 95% CIs of the simulated 5th, 50th and 95th percentiles. (a) Visual predictive check of all the data. (b) Visual predictive check of the first dose. (c) Visual predictive check of the last dose.