HFD intake altered inflammatory and oxidative stress signaling pathways in endometriotic lesions in a mouse model. A, The top 50 up- or down-regulated genes by HFD in ectopic lesions were determined from microarray analysis. Confirmation of gene expression changes for genes associated with inflammation (B) or oxidative stress (C) from CD or HFD lesions was performed by QPCR. Data (mean ± SEM) are expressed as FC from CD lesions and were obtained from n = 7 (CD) and 8 (HFD) lesions; *, P < .05 by Student's t test. Bars with numerical P values show tendency for significance.