Effect of rapamycin (Rap) on Ang II-induced acute dipsogenic and pressor responses. Rapamycin pretreatment (10 ng, 10 min, ICV) inhibited ICV Ang II (200 ng, 30 min)-evoked increase in the frequency (A), duration (B), and amount (C) of water intake. ICV Ang II-induced increase in MAP was not affected by rapamycin pretreatment (D). n = 4–8; *, P < .05, one-way ANOVA or t test.