Figure 2.
Figure 2. The KIR binding site on HLA-I. (A) KIR2DL1 binds to HLA-C allotypes with the C2 epitope. KIR2DL2/3 bind HLA-C allotypes with the C1 epitope. KIR3DL1 binds to HLA-B and HLA-A allotypes with Bw4 epitope. (B) The KIR binding site is located over the C-terminal end of the HLA-I bound peptide (green). (C) The KIR binding site incorporates peptide positions 7 and 8 (p7 & p8) of 9mer peptides. Figure generated with BioRender.

The KIR binding site on HLA-I. (A) KIR2DL1 binds to HLA-C allotypes with the C2 epitope. KIR2DL2/3 bind HLA-C allotypes with the C1 epitope. KIR3DL1 binds to HLA-B and HLA-A allotypes with Bw4 epitope. (B) The KIR binding site is located over the C-terminal end of the HLA-I bound peptide (green). (C) The KIR binding site incorporates peptide positions 7 and 8 (p7 & p8) of 9mer peptides.

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