Class B of GPCRs and the interaction of some interesting proteins with therapeutic targets in migraine. Proteins belonging to class B of GPCRs (A). Protein–protein interaction (PPI) of the proteins found in this study (highlighted in yellow) that interact with each other (red lines); in green are the neuropeptides widely associated with migraine, and in blue are some of the receptors that have been therapeutic targets for migraine (B).