Figure 5.
The zinc finger arrays of different PRDM9 alleles. The zinc fingers arrays corresponding to different rhesus macaque (top) and human (bottom) PRDM9 alleles are illustrated. Each zinc finger is depicted as an oval, in which the 3 DNA contacting residues (1, 3, and 6) are provided. Different zinc fingers are indicated by distinct colors. The 2 rhesus macaque zinc fingers (SFQ, DSY) with a bold lining are also found in human PRDM9 zinc finger arrays. The frequency of each allele in the characterized rhesus macaque cohort is provided, demonstrating 2 dominant allotypes. Three alleles, PRDM9*New1, PRDM9*New8, and PRDM9*New11, encode for identical zinc finger arrays.