Pairwise identity plots for the identification of recombination intervals. (A) The pairwise sequence identity of KIR3DL08 and KIR3DL02, KIR3DL08 and KIR3DLW43, and KIR3DL02 and KIR3DLW43 are depicted by yellow, blue, and red lines, respectively. (B) A similar plot is generated for the alignments of 3 gene tandems, involving KIR3DL05–KIR3DL07, KIR3DL01–KIR3DS02, and KIR3DL05–KIR3DS02. The identified recombination intervals, containing the putative double-stranded break, are indicated at 95% and 99% confidence intervals by gray highlighting. The nucleotide position is illustrated on the x-axis, with boxes indicating the position of the different exons in the sequence alignments. The striped black bar at the top represent regions where the aligned sequences deviate from one another, which helps to determine the recombination interval. The plots are generated using RDP4.⁴⁰