Overview of the rhesus macaque KIR haplotype panel. The 16 rhesus macaque KIR haplotypes are illustrated together with the 5 previously characterized haplotypes (indicated with an asterisk).23 Haplotype H15 was characterized in both studies. (Top) A schematic outline is depicted of a putative standard region organization. In this standard organization, KIR3DL20 (yellow) and KIR2DP (gray) are framework genes present in the centromeric region. A third gene, KIR1D, is present on approximately half of the haplotypes. The telomeric region features the presence of KIR2DL04 (green) and a diverse set of KIR3D genes, with inhibitory (blue) or activating (red) potential. Five KIR haplotypes follow the putative standard organization. The other haplotypes are classified based on 3 markers of meiotic recombination: the presence of hybrid KIR genes or multiple copies of particular KIR genes, or deviating region organizations. On 10 haplotypes, 1 or 2 hybrid KIR genes (orange) were identified. Two or more copies of a particular gene (bold outlined boxes) were found on 7 KIR haplotypes. The standard organization, with a clear separation of centromeric and telomeric haplotype segments, deviated on 3 haplotypes. Several haplotypes display multiple indications for recombination (e.g. haplotype H107 contains hybrid KIR genes and multiple copies of genes).
