Multi-functional peptides discovered by iMFP-LG from UniRef90

A. Candidate peptides with both anti-cancer and anti-microbial functions screened from UniRef90 by iMFP-LG. B. Multiple sequence alignment and phylogenetic tree of the candidate peptide UniRef90_P82904. C. Structure alignment of the candidate peptide UniRef90_P82904 with its homologous sequence. D. and E. Bacterial inhibition effects of peptides UniRef90_P56917 and UniRef90_P82904 on E. coli (D) and S. aureus (E). F. Cytotoxic effects of peptides UniRef90_P56917 and UniRef90_P82904 on HeLa, HepG2, and T24 tumor cells. G.–I. Dose-dependent cytotoxic effects of the candidate peptide UniRef90_P82904 on HeLa (G), T24 (H), and HepG2 (I) tumor cells. AA, amino acid; n.c., negative control.