Plot demonstrating the gene expression profiles of cells with varying TP53 statuses (wild-type versus mutant) in response to Idasanutlin treatment. (a) UMAP visualization of cells treated with DMSO control (violet) and Idasanutlin (yellow) against a diverse set of cell lines before dimensionality reduction. Two distinct clusters correspond to the two experimental conditions. (b) UMAP visualization of cells treated with DMSO and Idasanutlin against a diverse set of cell lines after dimensionality reduction.