Cumulative all-cause mortality hazard risk. All-cause mortality risk in patients with CS and matched controls during 25-years of follow-up. Time 0 marks the time of CS diagnosis for cases and the beginning of follow-up (at the exact age as their individually matched cases) for controls. (A) all patients with Cushing's syndrome, (B) patients with Cushing's disease, and (C) patients with adrenal Cushing's syndrome, compared with individually matched controls.