IR per 1000 PYs for (A) fungal and viral infections, (B) cardiac, vascular, and circulatory disorders, (C) hepatobiliary injury/disorders, (D) malignancies, (E) eye disorders for the UC overall, UC advanced therapy, UC trial-similar, and Non-UC cohorts assessed, stratified by age. *Indicates significant differences as determined by non-overlapping 95% CI values. CI, confidence interval; IR, incidence rate; NMSC, non-melanoma skin cancer; PY, patient year; UC, ulcerative colitis.