Differences of TL voxel-wised connectivity between groups and correlation patterns with clinical symptoms. (A) The significant differences of TL voxel-wised connectivity between dPHN (N = 17), ndPHN patients (N = 19), and HCs (N = 34) (ANCOVA, F = 8.511, P < 0.001, Alphasim-corrected, cluster size >22). (B) Visualisation of TL voxel-wised connectivity difference between dPHN and ndPHN patients. L, left; R, right. Coloured regions represent the difference of right IFG, which connect to right TL. (C) Correlation between TL-IFG connectivity and Positive-PANAS score (Partial correlation analysis. HC, N = 34, r = −0.14, P = 0.452; dPHN, N = 17, r = 0.583, P = 0.029; ndPHN, N = 19, r = 0.211, P = 0.433). (D) Correlation between TL-IFG connectivity and SF-36 score (Partial correlation analysis. HC, N = 34, r = −0.124, P = 0.507; dPHN, N = 17, r = 0.599, P = 0.024; ndPHN, N = 19, r = 0.344, P = 0.192). ANCOVA, analysis of covariance; dPHN, depressed postherpetic neuralgia; HC, healthy control; IFG, inferior frontal gyrus; ndPHN, non-depressed postherpetic neuralgia; PANAS, positive affect negative affect schedule; TL, temporal lobe; SF-36, the MOS 36-item short-form survey. Dots represent the TL-IFG connectivity value of each subject.