Differential secretion of pro- and anti-inflammatory mediators by neutrophils from high (HR) and low (LR) responder TB patients. Neutrophils from HR and LR TB patients were incubated at 2.5 × 10⁶ cells/ml during 2 h with Mtb-Ag (10 μg/ml). Afterward, the levels of (A) IL-8 and (B) CXCL10 were measured in cell-free culture supernatants by ELISA. Each point represents the individual value of cytokine production (pg/ml) ± SEM. Statistical differences were calculated using the Wilcoxon signed rank test for paired samples (**P < 0.01; ***P < 0.001; ****P < 0.0001) or the Mann-Whitney nonparametric test for unpaired samples (^#P < 0.05; ^###P < 0.001). N, HR=(A: 7; B: 8); N, LR=(A: 12; B: 10).