Cytokines released during unloaded, normothermic reperfusion. (A) IL-18 belongs to the IL-1 family and represents one of the key pro-inflammatory cytokines in the context of cardiac inflammation. (B) IL-10 is an anti-inflammatory cytokine known to be released in the context of cardiac ischaemia and reperfusion and acts to mitigate post-ischaemic necrosis and tissue remodeling. (C) The release of IFNγ is known to be triggered by IL-in the context of cardiac inflammation. CSS: cold static storage; HOPE: hypothermic oxygenated perfusion; IFNgamma: interferon gamma; IL: interleukin. n = 5 per group.