Figure 2.
Figure 2 presents two forest plots labeled Panel A (Overall Survival) and Panel B (Progression-free Survival), each derived from univariate Cox-regression analyses of multiple clinical and laboratory covariates. The horizontal axis in both plots is a logarithmic scale for hazard ratios (ranging roughly from 0.2 to 5), with a dashed vertical line at HR=1 serving as a reference. Covariates listed along the left margin include atezolizumab co-administration, age over 65, Ki-67 over 55%, gastrointestinal and genitourinary origins, liver metastasis, peritoneum metastasis, bone metastasis, lung metastasis, total bilirubin above the upper limit of normal (ULN), ALT above ULN, lactate dehydrogenase (LDH) above ULN, neutrophil-to-lymphocyte ratio (NLR) greater than 3, platelet count above ULN, and serum albumin below the lower limit of normal (LLN). Each row shows a black circle indicating the hazard ratio, with a horizontal line depicting the 95% confidence interval; numerical results (HR, CI, p-value) appear on the right.In Panel A (Overall Survival), two covariates show statistically significant associations with worse outcomes. Elevated LDH above ULN has an HR of 2.39 (95% CI, 1.29–4.41) with P=.005, and NLR greater than 3 has an HR of 2.58 (95% CI, 1.39–4.72) with P=.002; both confidence intervals lie entirely above HR=1. Other variables, such as atezolizumab co-administration, age over 65, Ki-67 over 55%, or metastatic status to various organs, generally cross the HR=1 line or show wide intervals, indicating no significant association with overall survival. In Panel B (Progression-free Survival), elevated LDH similarly demonstrates a statistically significant correlation with shorter PFS (HR=1.81, 95% CI, 1.05–3.12, P=.033), while the remaining covariates do not reach statistical significance.

Forest plots of univariate Cox regression analyses for overall survival (A) and progression-free survival (B), illustrating the hazard ratios and 95% CIs for various clinical and demographic factors.

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