Comparison of genomic alterations in patients with CRC with early (≤1 year from initial diagnosis) and late recurrence (>1 year from initial diagnosis). (A) Bar plot showing the prevalence of actionable alterations, (B) bar plot showing the prevalence of KRAS mutations, (C) volcano plot showing the comparison of alterations in all genes baited by F1 or F1CDx, and (D) bar plot showing the prevalence of gene alterations statistically significant in (C) in patients with MSS with no POLE/POLD1 mutation. (alt; alteration, amp; amplification, mut; mutation, re; rearrangement)