Diagnostic procedure scheme. We propose a decision tree based on the cyclin D1, CD10, and morphometrics parameter, followed by an ordinal scale based on growth pattern, follicular colonization, FDC network, IgD, and proliferation. NMZL determinant parameters: perifollicular growth pattern, follicular colonization present, intact or compressed FDC network, and low-intermediate Ki-67 (<40%). Aspects favoring NMZL: interfollicular growth pattern, expanded or disrupted FDC network, and IgD positivity. Aspects favoring nDLBCL: diffuse growth pattern, no residues of follicles, complete effacement of FDC network, and high Ki-67 (above 40%). For the cases for which none of the parameters has a determinant value, we propose to apply a majority vote with the 5 parameters equally taken into consideration. FDC, follicular dendritic cell; nDLBCL, nodal diffuse large B-cell lymphoma; NMZL, nodal marginal B-cell lymphoma.