Inflammasome activator induces and antioxidants/inhibitors suppress. Neutral thyrotropin receptor antibodies (N-TSHR-mAbs) induced NLRP3 and interleukin (IL)-1β production. Similar to MnTBAP and NAC (n-acetyl-l-cystine), cyclic adenosine monophosphate (cAMP) also reduced free radicals and inhibited inflammasomes including IL-1β. *P less than .05.