Robustness, fitness, and genome architecture across generations for $μ=1.6×10−5$ (⁠$16μ0$⁠) per base pair for each mutation type and $N=1,024$ (⁠$N0$⁠) (top row, panels a, b, and c) and $N=16,384$ (⁠$16N0$⁠) and $μ=1×10−6$ (⁠$μ0$⁠) per base pair for each mutation type (bottom row, panels d, e, and f). Lines represent the mean values across the 50 simulations, and the shaded areas represent the standard deviations.