Figure 4.
Infliximab improves dysbiosis in the presence of colitis. Panels A and B: Shannon index box plots illustrating preserved microbial alpha diversity in colitis-bearing WT and octn1-/- mice treated with IFX. P values, corrected for FDR, have been obtained by Mann-Whitney test. Panels C and D: PCoA plots of Bray Curtis dissimilarity matrix showing lack of sample clustering by IFX treatment. P values have been computed by PERMANOVA test. Panels E and F: Relative abundance comparisons between DSS-treated mice for both strains with or without IFX. Statistics by the DESeq2 method.