Mean change in 24-hour BP from baseline up to 36 months in the SPYRAL HTN-ON MED trial. A) 24-hour systolic BP. B) 24-hour diastolic BP. *Mean sham-control measurements at 36 months include 13 imputed crossover patients’ BP values from the most recent measurements before the RDN procedure. Error bars are standard errors (SE). Adapted with permission from²⁸. BP: blood pressure