Pre-specified subgroup analysis according to the P2Y₁₂ inhibitor used after aspirin discontinuation vs. standard DAPT. The figure illustrates the treatment effect estimate for each P2Y₁₂ inhibitor monotherapy after DAPT de-escalation by aspirin discontinuation compared with standard DAPT. Circles and lines represent OR and 95% CI, respectively. NNT are reported as NNT for benefit, except for those highlighted by *, representing NNT for harm. Conclusiveness for futility in the TSA means that performing another trial comparing the same treatment and control in a similar population will lead to the same inconclusive result, without substantially improving the overall evidence on the topic. Abbreviations: CI, confidence interval; DAPT, dual antiplatelet therapy; GRADE, Grading of Recommendations, Assessment, Development, and Evaluations; I²_p, I² pooled; MACE, major adverse cardiovascular events; NACE, net adverse clinical events; NNT, number needed to treat; OR, odds ratio; P_int, P-value for interaction; TSA, trial sequential analysis.