Figure 5.
Boxplot of PPGL primary cultures after 72 hours incubation with 5 µM CBD: comparison between cluster 1-related (red) and cluster 2-related (blue) tumors. PPGLs with PVs in NF1 are shown in light blue. Additionally, there is a comparison of cluster 1-related and cluster 2-related tumors with tumors without germline PV (and without cluster 1/2 somatic PV or with unknown somatic status) (black). Each cell viability experiment comprised 3 to 8 samples per drug concentration and patient. The mean values are shown as 1 dot. This figure was created with the open-source statistics software R (Version 4.3.1, R Foundation for Statistical Computing, Vienna, Austria). *P < .05.

Boxplot of PPGL primary cultures after 72 hours incubation with 5 µM CBD: comparison between cluster 1-related (red) and cluster 2-related (blue) tumors. PPGLs with PVs in NF1 are shown in light blue. Additionally, there is a comparison of cluster 1-related and cluster 2-related tumors with tumors without germline PV (and without cluster 1/2 somatic PV or with unknown somatic status) (black). Each cell viability experiment comprised 3 to 8 samples per drug concentration and patient. The mean values are shown as 1 dot. This figure was created with the open-source statistics software R (Version 4.3.1, R Foundation for Statistical Computing, Vienna, Austria). *P < .05.

Abbreviations: CBD, cannabidiol; ns, nonsignificant; PPGL, pheochromocytoma and paraganglioma; PV, pathogenic variant.

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