Adenosine kinase inhibitor ABT702 reduces CaCl₂-induced AAA in mice. (A) Experimental schematic representation of CaCl_2-induced AAA in wild-type male mice treated with vehicle or ABT702. (B) Representative images of abdominal aortas from vehicle- and ABT702-treated mice at 6 weeks after saline or CaCl₂ application. (C) Maximal abdominal aortic diameter in vehicle- and ABT702-treated mice at 6 weeks after saline or CaCl₂ application (n = 5–12). (D) Representative staining with elastin (left) and elastin fragmentation score (right) in abdominal aortas from vehicle- and ABT702-treated mice at 6 weeks after saline or CaCl₂ application (n = 5–12). (E) Representative images of LGALS3 immunofluorescent staining (left) and quantification of LGALS3⁺ cells (right) in abdominal aortas from vehicle- and ABT702-treated mice at 6 weeks after saline or CaCl₂ application (n = 6–8), L: lumen, scale bar = 50 μm. (F) qPCR analysis of inflammatory cytokines and (G) MMPs in abdominal aortas from vehicle- and ABT702-treated mice at 6 weeks after CaCl₂ application (n = 6). Two-way ANOVA followed by Tukey post hoc test for (C) and (E), Kruskal–Wallis test followed by Dunn’s post hoc test for (D), two-tailed unpaired Student’s t-test for (F) and (G, Mmp2, Mmp3, and Mmp12), and two-tailed unpaired Student’s t-test with Welch’s correction for (G, Mmp9). All data are represented as mean ± SEM *P < 0.05, **P < 0.01, and ***P < 0.001 for indicated comparisons.