AGT and RAAS pathway and its inhibition by nucleic acid-targeted therapies. Renin acts upon its substrate angiotensinogen, which is produced by the liver, to produce angiotensin I. ACE plays a crucial role in the pathway by converting angiotensin I into angiotensin II. ACE is primarily located on the surface of endothelial cells in the lungs, where it carries out this conversion. Besides vasocontriction, angiotensin II has effects on several tissues and organs. It promotes endothelial dysfunction, sympathetic activation, ventricular hypertrophy; stimulates aldorsterone secretion and sodium retention, ultimately causing increase in blood pressure. New drugs can inhibit the secretion of AGT protein by targeting the AGT mRNA. AT1R, angiotensin II receptor 1; ACE, angiotensin converting enzyme.