Major adverse cardiovascular event rate during follow-up in (A) calcium-positive and calcium-negative LDCT and (B) risk groups based on automatic calcium scoring from LDCT scans. Risk groups were defined as follows: 0, 0 AS; 1, 1–100 AS; 2, 101–400 AS; 3, 401–1000 AS; and 4, >1000 AS.⁷