Implant success and peri-procedural safety of left atrial appendage closure. Over the last decade, implantation success and peri-procedural safety have improved due to developments in implantation technique, accumulating operator experience, and device development. (A) Implantation success is illustrated for multicentre registries and randomized trials over time. (B) Severe adverse events within 7 days post-implantation are shown consisting of vascular complications/bleeding, pericardial effusion/tamponade, stroke, and device embolization