Association of the EGLN1 G/A SNP (Chr25:3,503,284 bp) with different altitudes

A. The zoom-in GWAS signals on Chr25. LD between the G/A SNP and other variants is quantified by the squared Pearson coefficient (r²). B. Allele frequency of the G/A SNP between the high-altitude and low-altitude sheep. C. Allele frequency of the putatively adaptive G allele in worldwide sheep populations. D. The expression level of mRNA in the G/A SNP region and its corresponding genotypes. E. The exonic expression of EGLN1 in the muscle between the high-altitude and low-altitude sheep. F. The epigenetic signals in the region encompassing the putatively adaptive G allele. G. Splice junction patterns between exons 2 and 4. The two transcripts of EGLN1 at the corresponding positions are shown at the bottom. The numbers in red indicate the reads shared between the two transcripts; each number corresponds to a sample, and the numbers are separated by commas. UTR, untranslated region.