Dose-dependent effect of physical activity on cardiovascular outcomes among participants, stratified by genetic risk for type 2 diabetes. (A and B) Restricted cubic spline analysis of physical activity (metabolic equivalents hours per week) and the hazard ratio for three-point major adverse cardiovascular events (A) or four-point major adverse cardiovascular events (B) among participants with diabetes. Dashed lines indicate 95% confidence interval. (C and D) Restricted cubic spline analysis of physical activity (metabolic equivalents hours per week) and the hazard ratio for three-point major adverse cardiovascular events (C) or four-point major adverse cardiovascular events (D) by quartile of polygenic risk score for type 2 diabetes. Dashed lines indicate 95% confidence interval.