Effect of type 2 diabetes polygenic risk–physical activity interaction on cardiovascular outcomes in participants with diabetes. (A) Effect of each 10 metabolic equivalents hours per week of physical activity on the hazard ratio for three-point major adverse cardiovascular events among participants with diabetes, by quartile of polygenic risk score for type 2 diabetes. Adjusted for age, sex, body mass index, haemoglobin A1c, duration of diabetes, and use of insulin, sulfonylurea, metformin, thiazolidine, or statin. (B) Effect of each 10 metabolic equivalents hours per week of physical activity on the hazard ratio for four-point major adverse cardiovascular events among participants with diabetes, by quartile of polygenic risk score for type 2 diabetes. Adjusted for age, sex, body mass index, haemoglobin A1c, duration of diabetes, and use of insulin, sulfonylurea, metformin, thiazolidine, or statin.