Structure-based alignment of rat and yeast GGTase-I β subunits. The structure of the rat (blue) and yeast (gray) GGTase-I β subunits was derived from PDB 1n4p and an AlphaFold predicted structure, respectively (Jumper et al. 2021). Active site amino acids are color coded to match the structures; the active site zinc ion is the green sphere; the geranylgeranyl pyrophosphate is indicated in yellow and other colors. Alignment of the structures and an RMSD calculation were performed using the Align function of PyMol.