Frequencies of the most common endocrine signs and symptoms of adrenal hormone excess in ACT in 63 prepubertal females (A), 47 pubertal females (B), 34 prepubertal males (C), 11 pubertal males (D), and in prepubertal (E) and pubertal (F) patients combining female and male patients. Legend:   acne pubarche clitoral hypertrophy penile growth weight gain hypertension excessive pubic hair cushingoid appearance tall stature clitoral hypertrophy/penile growth deep voice hirsutism tiredness abdominal and back pain.