EP detection and regulatory element density in the region. (a) Significant EPs called by Gasperini2019 show stronger Hi-C contact in high-density regions. (b) Mean and median Hi-C contact is lower in high-density regions. (c, d) Absolute counts of False Positives (FP) and False Negatives (FN) and True Positives (TP) for ABC and XGB. (e) Proportion of False Negatives increase while False Positives decrease with density in ABC models. (f) Proportion of False Positives and False Negatives both increase with density in XGB models. (g, h) Hi-C contact strength for True Negatives (TN), FP, FN, and TP in (g) ABC and (h) XGB models