Significant correlation between TUG1 expression levels and clinical phenotypes in Friedreich's ataxia patients. (A–D) Scatter plots and linear regression models illustrate the relationship between TUG1 expression levels and various clinical phenotypes. (A) As anticipated, a significant association is observed between the FDS and age. (B) A significant negative correlation is present between disease onset and TUG1 fold-change (P < 0.05). (C) A substantial positive correlation exists between TUG1 fold-change and disease duration (P < 0.05). (D) The FDS also shows a significant positive correlation with TUG1 fold-change, highlighting its potential as a biomarker for disease severity.