In-hospital mortality rates at 14 and 28 days among patients hospitalized for coronavirus disease 2019 (COVID-19) and not requiring supplemental oxygen at admission, across the COVID-19 variant time periods (adjusted Cox proportional hazards model). Estimates were adjusted for age, admission month, hospital ward on admission (intensive care unit/step-down vs general ward), and baseline treatments (anticoagulants, convalescent plasma, corticosteroids, baricitinib, or tocilizumab). Abbreviations: aHR, adjusted hazard ratio; CI, confidence interval.