Statistics of virus diversity in treated and untreated populations. (A) Increases in the mean number of variants per viral genome were observed in populations treated with increasing doses of favipiravir. Black dots show genome-wide statistics calculated from populations: Each dot represents the viral population in a single hamster. The red square shows the mean value for populations treated with 300 mg favipiravir and 150 mg molnupiravir. The blue square at 500 mg molnupiravir shows a datapoint that was omitted from the regression calculation; this point is discussed in the main text. Shading indicates a 95 per cent confidence interval for the regression line. A horizontal dashed line indicates the model threshold at the point of effective treatment. (B) Increases in the mean number of variants per viral genome per virus were observed in populations treated with increasing doses of molnupiravir. (C) Composition of variants denoted by variant frequency, ordered by favipiraivir dose. Bars show the total number of variants per genome (plotted as points in Fig. 1A), decomposed into the contributions to this total from variants of different frequencies. Each bar describes statistics for the viral population in a single hamster. (D) Composition of variants denoted by variant frequency, ordered by molnupiravir dose. Bars show the total number of variants per genome (plotted as points in Fig. 1A), decomposed into the contributions to this total from variants of different frequencies.