Serum concentrations of insulin, C-peptide, and glucose. Insulin (A), C-peptide (B), and glucose (C) presented as absolute values during test days with subcutaneous injection of GIP (circle), GLP-2 (square), or placebo (triangle). Data are shown as mean ± SEM. Data were analyzed using a mixed-effects model for the period t = −10 to t = 240 minutes with Geisser–Greenhouse correction and Holm–Sidak multiple comparison tests with interventions compared to placebo. Symbols indicate a significant difference (P < .05) between placebo and GIP (α).

Abbreviations: GIP, glucose-dependent insulinotropic polypeptide; GLP-2, glucagon-like peptide-2.