The overall framework of MIDTI. In Step 1, MIDTI constructs the integrated similarity networks of drugs and targets with their multisource information, as well as the drug–target bipartite network and the drug–target heterogeneous network. In Step 2, MIDTI learns the embeddings of drugs and targets from multiple networks respectively. In Step 3, MIDTI adopts the deep interactive attention mechanism to learn discriminative representations of drugs and targets. In Step 4, MIDTI predicts the potential DTIs with the MLP classifier.