Comparison of differences in genomic alterations between MTAP-loss and MTAP-intact tumors in the Genomics-only cohort. The distribution of co-occurring potentially targetable and un-targetable genomic alterations in advanced (A) pancreatic ductal adenocarcinoma (PDAC), (B) intrahepatic cholangiocarcinoma (IHCC) (C) colorectal carcinoma (CRC), (D) gastroesophageal adenocarcinoma (GEAC), and (E) hepatocellular carcinoma (HCC) are shown. Striped bars represent MTAP-intact groups, solid bars represent MTAP-loss groups, and numbers represent (%) within tumor group. *P ≤ .05; **P ≤ .01; ***P ≤ .001; ****P ≤ .0001.