SIV-related mRNA and circRNA changes in bdEVs and BH. A, Correlations of sRNA log₂FC in bdEVs and BH: acute versus uninfected. The linear regression line, pearson correlation coefficient (R), and significance (P) are shown for all DE sRNAs, acute versus uninfected. B, Correlations of sRNA log₂FC in bdEVs and BH, CP+ versus uninfected. The linear regression line, pearson correlation coefficient (R), and significance (P) are shown for all DE sRNAs, CP+ versus uninfected. C, Levels of circ-IFI6_0001(left) and IFI6 (right) in bdEVs and BH. *Adjusted P < .05 per edgeR. D, Putative ceRNA network. The rectangle nodes represent circRNAs, the oval nodes represent miRNAs, and the hexagon nodes denote mRNAs. Edges are interactions between RNAs. Abbreviations: bdEVs, brain tissue-derived extracellular vesicle; BH, brain homogenate; circRNA, circular RNA; CP, central nervous system pathology; FC, fold change; mRNA, messenger RNA; SIV, simian immunodeficiency virus; sRNA, small RNA.