Local reactions (A) and systemic events (B) reported within 7 days of vaccination. Data are for the safety population. Severity grading of the specific local reactions and systemic events is provided in Supplementary Table 1. Error bars represent 95% CIs computed using the Clopper-Pearson method and numbers above the bars indicate the percentage of participants in each group reporting the specified event (rounded to whole numbers). Local reactions were reported by participants at the RSVpreF or placebo injection site only. RSVpreF + SIIV (n = 701); placebo (n = 681); placebo + SIIV (n = 693); RSVpreF alone (n = 686). Abbreviations: CI, confidence interval; RSVpreF, respiratory syncytial virus prefusion F protein–based vaccine; SIIV, seasonal inactivated influenza vaccine.