New PTMs in the TLR4 signaling pathway involved in inflammatory response A. Regulated proteins in the TLR4 pathway are grouped by function, and arrows indicate the direction of signal transduction. The colors on the left and right represent Log2 ratio of the indicated proteome datasets from cells stimulated with LPS for 0.5 h and 2 h, respectively. PTM sites with known functions based on UniProt and previous studies are colored in red [30–40]. B. Heatmap representation of the intensity of proteins and PTM sites involved in inflammatory signaling pathways detected in cells stimulated with LPS for 0.5 h and 2 h.