This visual summary delineates the cardiovascular risks and mortality associated with syphilis infection, presenting hazard ratios for key outcomes. These include new-onset acute myocardial infarction, heart failure, aortic regurgitation, aneurysm and/or dissection of the aorta, atrial fibrillation, ischaemic stroke, haemorrhagic stroke, venous thrombo-embolism (deep vein thrombosis or pulmonary embolism), cardiovascular death, and all-cause mortality.¹¹