Figure 2.
Summary characterization of thyroid microtissue endpoints at day 14. Thyroid microtissues for the total donor cohort (N = 32) were evaluated for (A) adenosine triphosphate (ATP) relative light units (RLU) as an indicator of biomass, (B) thyroglobulin protein production (ng/ml), (C) T3 hormone synthesis (ng/ml), (D) T4 hormone synthesis (ng/ml), and (E) T4/T3 ratio (ng/ml). Treatment groups included: Tx-1 (negative control), Tx-2 (positive control), and Tx-3 (TSH antagonist control). The summary distributions are represented in the box and whisker plots as the 1st percentile, 25th percentile, median, 75th percentile, and 99th percentile. The “+” symbol represents the mean value. ** (p ≤ .05), *** (p ≤ .01), *** (p < .001). Not significant (ns).

Summary characterization of thyroid microtissue endpoints at day 14. Thyroid microtissues for the total donor cohort (N = 32) were evaluated for (A) adenosine triphosphate (ATP) relative light units (RLU) as an indicator of biomass, (B) thyroglobulin protein production (ng/ml), (C) T3 hormone synthesis (ng/ml), (D) T4 hormone synthesis (ng/ml), and (E) T4/T3 ratio (ng/ml). Treatment groups included: Tx-1 (negative control), Tx-2 (positive control), and Tx-3 (TSH antagonist control). The summary distributions are represented in the box and whisker plots as the 1st percentile, 25th percentile, median, 75th percentile, and 99th percentile. The “+” symbol represents the mean value. ** (p ≤ .05), *** (p ≤ .01), *** (p < .001). Not significant (ns).

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