Comparison risk threshold of the PLN p.(Arg14del) risk model in the LM-0 and LM-3 cohort. The y-axis represents the clinical implication of the chosen risk threshold on the x-axis with the PLN p.(Arg14del) risk model in the LM-3 cohort (n = 268 patients) (A) and the LM-0 cohort (n = 679 patients) (B). The cohorts are divided by proportions of subjects experiencing major VA as well as implantable cardioverter defibrillator (ICD) implantation. (C) Represents the comparison between the LM-0 and LM-3 cohort (blue and orange line, respectively) of ‘missed’ subjects with major VA and without ICD implantation. PLN, phospholamban; VA, ventricular arrhythmia.