Flow diagram depicting the selection of patients with initial Clostridioides difficile infection for chart review and inclusion in the analysis. Abbreviations: CDI, Clostridioides difficile infection; EIP, Emerging Infections Program. ^aPatients with community-onset CDI who underwent a full chart review were less likely than those without a chart review to be community-associated (71.0% vs 93.3%; P = .004), but there were no differences in the proportion who were female (P = .10), aged ≥65 y (P = .93), or who had multiple recurrent CDI (P = 1.00) or died within 180 d of initial CDI (P = .69). ^bPatients with healthcare facility-onset CDI (ie, hospital-onset or long-term care facility onset CDI) who had a full chart review were less likely than those without a chart review to be long-term care facility-onset (32.7% vs 38.5%; P = .004), but there were no differences in the proportion who were female (P = .19), aged ≥65 y (P = .32), or who had multiple recurrent CDI (P = .51), or died within 180 d of initial CDI (P = .48).